Optimizing cell arrays for accurate functional genomics
نویسندگان
چکیده
منابع مشابه
Tandem gene arrays: a challenge for functional genomics.
In sequenced plant genomes, 15% or more of the identified genes are members of tandem-arrayed gene families. Because mutating only one gene in a duplicated pair often produces no measurable phenotype, this poses a particular challenge for functional analysis. To generate phenotypic knockouts, it is necessary to create deletions that affect multiple genes, select for rare meiotic recombination b...
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Genomic methods are used increasingly to interrogate the individual cells that compose specific tissues. However, current methods for single cell isolation struggle to phenotypically differentiate specific cells in a heterogeneous population and rely primarily on the use of fluorescent markers. Many cellular phenotypes of interest are too complex to be measured by this approach, making it diffi...
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Professor Ryan McLean and others at Caltech have developed a new, cheaper radiation sensor using CdZnTe materials. Professor K. Mani Chandy and the Infospheres research group have developed algorithms for aggregating the data collected by many of these sensors working in concert. This paper considers the optimal placement for such sensors. This paper concludes that stationary sensors are far in...
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ژورنال
عنوان ژورنال: BMC Research Notes
سال: 2012
ISSN: 1756-0500
DOI: 10.1186/1756-0500-5-358